Eligibility
For the CLASSIC trial
Inclusion criteria
All the following criteria must be fulfilled:
Ѵ Aged 18 years or above
Ѵ Admitted to the ICU or plan to be admitted to the ICU regardless of trial participation
Ѵ Septic shock defined according to the Sepsis-3 criteria:
- Suspected or confirmed site of infection or positive blood culture AND
- Ongoing infusion of vasopressor/inotrope agent to maintain a mean arterial blood pressure of 65 mmHg or above AND
- Lactate of 2 mmol/L or above in any plasma sample performed within the last 3-hours
Ѵ Have received at least 1 L of IV fluid (crystalloids, colloids or blood products) in the last 24-hours prior to screening